Almac Discovery has selected a preclinical development candidate from its allosteric Akt inhibitor program. Akt, a component of the PI3K pathway, is associated with driving tumor growth in many cancer types. ALM301, a potent, subtype selective Akt1 & Akt2 inhibitor, has demonstrated efficacy in prostate, breast and other cancer models, both as a single agent and in combination with other chemotherapeutic agents.   Effects on tumor growth inhibition in these studies also correlate with Akt pa...